• 专利附录
  • 专利说明
  • 权利要求
  • 类似技术
  • 同族专利
  • 引用文献
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  • 优先权
    • 专利摘要:
    A method for on-line monitoring of the integrity of a filtering system implemented during an industrial process comprising filtering a gas through said filtering system, said filtering system comprising at least one filtering cartridge, comprising least the following steps: - a measurement step (S1) during which a pressure difference AP representative of the pressure drop generated by the filtering system (F1; F2) is measured, - a step (S2, S3) of test in which said measurement (S1) is compared with a predetermined high threshold (Sh) and a predetermined low threshold (Sb) so as to consider said at least one non-compliant filter cartridge when the pressure difference measured at the measurement step (S1) leaves a range between said high threshold (Sh) and said low threshold (Sb).
    公开号:FR3021112A1
    申请号:FR1454355
    申请日:2014-05-15
    公开日:2015-11-20
    发明作者:David Segard
    申请人:Roquette Freres SA；
    IPC主号:
    专利说明:

    [0001] The present invention relates to a method of online monitoring of the integrity of a filter system. The field of the invention is that of industrial processes comprising a step of filtering a gas through a filter system.
    [0002] The invention will find a particular application in industrial processes using filtration to sterilize a gas, such as for example air, and in particular industrial fermentation processes. In the field of fermentation, it is known from the state of the art of facilities comprising a fermentation reactor, hereinafter called "fermenter", in which the fermentation reaction takes place, generally under conditions of temperature and temperature. controlled agitation. These installations comprise compressors and pipes that convey a gas, in this case air, into the fermentation plant, in contact with the fermentable product, or in contact with a material intended to feed the fermentation reaction. . Thus, the air can be conveyed directly into the fermentor tank, particularly when aerobic fermentation is desired. Alternatively or additionally the gas may be used for the pneumatic transport of a carbon-rich material such as glucose to be fed to the fermentation reactor. In this case, the gas is used to push the material from a storage tank to the fermentor tank. In both cases, the gas must be sterilized in order to avoid any contamination (direct or indirect) of the products in the fermenter. For this purpose, the installation comprises filtering systems on the gas circuit whose function is to sterilize the gas by retaining the bacteria in suspension. This type of system comprises in practice a housing receiving a plurality of filter cartridges, called sterilizing. These sterilizing cartridges are characterized by their ability to retain bacteria whose particle size is of the order of a tenth of a micrometer.
    [0003] These filter cartridges are consumables and should be changed when too dirty. In certain industrial processes and in particular in fermentation processes, it is imperative to change the filter cartridges before too much clogging of the filter medium. These heavily fouled cartridges cause energy losses and loss of flow related to the pressure drop. It is also imperative to change the filter cartridges before the deterioration of the filter (related to aging, a pressure stroke) that creates the risk of dropping fibers and / or contaminations. For some industrial fermentations, the appearance of a contamination is unacceptable and involves emptying the fermenter, to put its contents to the waste, then to sterilize the fermentation plant before the implementation of a new production. Contamination causes significant production stoppages. In order to avoid such inconvenience, it is customary to periodically renew the filter cartridges, in a preventive manner, without actually knowing their state of integrity. Thus, and for industrial fermentations, the present Applicant proceeds to change the cartridges periodically every 12 months. The person skilled in the field of filtration also knows various tests for the control of a filter, and in particular: 1) The bubble point test: this test makes it possible to detect the presence of leaks through the filter . The filter is first immersed in a water / ethanol solution and then subjected to a determined, fixed pressure. The observation of a bubbling reveals a leak. 2) Diffusion test: The cartridge must be wetted with a water / ethanol solution. Pressure is applied and the flow through a precise measurement is quantified. 3) The pressure maintenance test: The cartridge must be wetted with a solution, for example water / ethanol. Pressure is applied and the loss of this pressure is observed over a given time. 4) The water intrusion test: this test commonly called WIT (for "Water Intrusion Test") allows to test sterilizing cartridges without alcohol, only with water. 5) Aerosol test: This test requires the diffusion of an aerosol of particles (oil mist), between 0.2 and 0.3 micrometers, then the laser count at the outlet of the particles having passed through the filter.
    [0004] These different tests have the following drawbacks: - they are not always feasible for all types of gas filter cartridge, - they require access to the clean characteristics of the filter cartridge that the manufacturer can keep secret, - they require for most pre-treatment of the cartridges before the test (ie wetting). In addition, all of these tests often require extracting the filter cartridge from its box, before performing the test. In any case, none of the aforementioned tests makes it possible to control the integrity of a filtering system, in line, that is to say, during the filtration of the gas for the implementation of the industrial process. It is still known from the state of the art, in filtration systems to use gauges to know the state of the filter. According to the findings of the inventors, the manometers used for this application have a sensitivity of +/- 250 millibars (25000 Kilo Pascals) and only allow to observe that the filters of the filtering system have arrived at their maximum pressure drop (data provided by the manufacturer of the filter cartridge), with the risk of clogging, over-consumption, reduced flow rate, blockage of fermentation.
    [0005] According to the findings of the inventors, and prior to a lack of integrity, the use of filter cartridges with significant fouling generates a loss of charge which leads to over-consumption of electric compressors used to route the gas and perform the filtration. In industrial processes for which the gas flow rate (normal flow rate) is typically much higher than 100 Nm3 / H, or even often higher than 1000Nm3 / H, this pressure drop results in a consequent additional power consumption.
    [0006] The object of the present invention is to overcome all or part of the aforementioned drawbacks by proposing a method of monitoring the integrity of a filter system, online, thus making it possible to check the integrity of the filtering system during said industrial process, during the implementation of filtration through said filter system. More particularly, and in the case of a filtering system sterilizing filter cartridges, an object of the invention is to provide such a control method that warns the user of the need to change the filter cartridges, before that contamination is to be deplored. Another object of the present invention is to provide such a control method which can be implemented, advantageously, without knowing the intrinsic technical specifications of the filter cartridges of the system. Another object of the present invention is, at least as one embodiment, to provide an on-line control method which can warn the user of the need to change the filter cartridges, and in the aim of avoiding overconsumption of the compressors used to carry out the filtration. Other advantages of the present invention will become apparent from the following description which is given for information only and which is not intended to limit it. The invention relates to a method for online monitoring of the integrity of a filtering system used during an industrial process comprising the filtration of a gas through said filtering system, said filtering system comprising at least one filter cartridge, process comprising at least the following steps: a measurement step during which a pressure difference 4P representative of the pressure drop generated by the filtering system is measured, a test step in which one comparing said measurement with a predetermined high threshold and a predetermined low threshold so as to consider said at least one non-compliant filter cartridge when the pressure difference measured at the measuring step is outside a range between said high threshold and said low threshold. The invention will be better understood on reading the following description accompanied by the appended drawings among which: FIG. 1 is a schematic view of an installation for the implementation of an industrial fermentation process and on which implement the control method according to the invention. - Figure 2 is a graph representing ordinate the pressure difference 4P measured, and abscissa the time, with triggering a warning signal fouling. FIG. 3 is a graph representing the measured 4P pressure difference on the ordinate, and the time on the abscissa, with the triggering of a leak warning signal. FIG. 4 is a graph representing, on the ordinate, the measured pressure difference 4P, and on the abscissa the time, the curve of which has a sudden variation interpreted as an anomaly (for example de-clogging or leakage). - Figure 5 is a diagram illustrating the various steps of a method according to the invention, which steps can be implemented automatically by computer means. - Figure 6 is a photo of a filter system whose housing receives twenty filter cartridges, of the sterilizing type. FIG. 7 is a photograph of a test bench made by the present Applicant to confirm the relevance of the control method according to the invention. The invention was born from the desire of the present Applicant to obtain a better monitoring of the sterility of the gases coming into contact with the products in industrial fermentations, and in particular fermentations sensitive to contaminations. FIG. 1 schematically illustrates a fermentation plant which comprises a fermentation reactor R, also called a fermentor. The fermenter comprises a tank inside which fermentable products ferment under controlled conditions. Such a fermenter may typically include exchangers to control the temperature of the reaction, and a rotor / stator torque to stir the products in the vessel.
    [0007] The installation may comprise a source of compressed air and a duct conveying air directly to the fermentation reactor R. In order to prevent the contamination of the fermentable products, this air is filtered prior to its entry into the reactor by a system filter identified Fi. Such a filter system Fi typically comprises a housing with an inlet for the unfiltered gas, and an outlet for the filtered gas. In this casing are removably received a set of filter cartridges, typically arranged to perform gas filtration in parallel. The plant may further include a G1 reservoir for a carbon-rich material, typically glucose. Another gas line, connected to the source of compressed air connects the tank G1 and serves to push the material contained in the tank G1 in a pipe and to the fermentation reactor. Prior to entering the tank G1, this air is filtered in another filter system F2 to avoid contaminating the carbon-rich material.
    [0008] In order to avoid contamination, the filtering systems Fi and F2, respectively, use sterilizing filter cartridges whose pore diameter is less than or equal to 0.22 μm, allowing the retention of microorganisms. During fermentation, it is important to monitor the integrity of the cartridges to avoid the appearance of contamination. These appear when the cartridges are unhealthy: an unhealthy cartridge can be the result of a preferential passage (a leak). Again, an unhealthy cartridge may be the result of too much fouling, very often accompanied by a significant risk of jettisoning the fibers of the media-filtering.30 In order to avoid any inconvenience, and to the knowledge of the inventors, it It is customary to periodically renew the filter cartridges, without knowing precisely their state of integrity, in a preventive manner, for example every 12 months.
    [0009] Desiring to obtain an online monitoring of its process, the present Applicant has become closer to the various actors specialized in sterilizing filtrations, namely the manufacturers of gas sterilizing cartridges and apparatus for testing the integrity of such gas cartridges.
    [0010] The solutions proposed by these actors were limited to the previously mentioned test solutions, namely "bubble point test", "pressure maintenance test", "diffusion test", "water introduction test" , and the "aerosol test". None of these solutions was chosen because of the aforementioned drawbacks and their very high implementation costs. In addition, none of the above tests can control the integrity of a filter system, in line, that is to say, during filtration of gas by the filter system and for the needs of the industrial process. It is to the credit of the present Applicant to have devised a method for controlling the integrity of a filtering system (F) that makes it possible to monitor the integrity of the filtering system, on-line, that is to say without disrupt the industrial process and gas filtration performed during this process. The invention finds a particular application for the monitoring of filtration systems used in an industrial fermentation, in particular implemented in an installation of the type of that illustrated in FIG. 1. However, the integrity control method n ' is not limited to this industrial process and can find a particular application in other industrial processes, and in particular those where one meets similar requirements on the filtered gas.
    [0011] Also the invention relates to a method for controlling the integrity of a filter system Fi; F2, said filter system Fi; F2 comprising at least one filter cartridge, namely a filter cartridge, or, preferably, several filter cartridges. In the latter case, the filter cartridges preferably provide parallel filtration of the gas. It is an online process implemented during an industrial process comprising the filtration of a gas such as air through the filter system Fi; F2. This test is therefore carried out during the filtration of the gases for the purpose of the industrial process, at the operating flow rate of the process, which is preferably a substantially constant flow rate. This flow rate (normal flow) may be greater than or equal to 100 Nm3 / H, or even often greater than or equal to 1000 Nm3 / H.
    [0012] In the case where the filter system Fi; F2 comprises a plurality of filter cartridges, said pressure difference measured in the measurement step Si is representative of the pressure drop generated by all the filter cartridges.
    [0013] The invention arose from the desire of the present Applicant to control the integrity of the filtering system by precisely monitoring the pressure drop generated by the filtering system, during filtration performed for the needs of the industrial process, at the flow rate. process gas operation.
    [0014] The invention thus ensures continuous monitoring throughout the fermentation, and ensures the integrity and sterility of the circuit during operation. According to the invention, said method thus comprises a measurement step 51 during which a pressure difference 4P is measured representative of the pressure drop generated by the filter system Fi; F2. For this purpose, a device for measuring a pressure difference is preferably used, said device having a first pressure connection C1, downstream of the filtering system and a second pressure connection C2, upstream of the pressure system. The measured pressure difference 4P is the pressure difference between the first connection Ci and the second connection C2. This measuring device differs from the manometers commonly used in such processes as end-of-life control, by the measurement sensitivity which may be less than or equal to 10 millibars (1000 Pascals), preferably less than 7.5 millibars. (750 Pascals). By sensitivity of the measurement is meant here the smallest quantity that the measuring device is able to discern. After several experiments, the inventors have determined that a device for measuring sensitivity less than 750 Pascals, or even less than or equal to 300 Pascals, or even a sensitivity of between 50 Pascals and 300 Pascals represented a good compromise between the cost of the device and the control method to implement.
    [0015] In practice, this sensitivity has been determined by the inventors as a percentage of the order of 5% (or less) of the value 4P0 representative of the pressure drop generated by the filtering system when the at least one filter cartridge is new. Typically and in a cascade filter system grouping and receiving a plurality of filter cartridges, it is customary to obtain values for 4P0 close to 100 millibars (10,000 Pascals), for example between 50 millibars (5,000 Pascals) and 150 millibars (15000 pascals). The measurement scale of the device preferably extends over a range of between 75 000 pascals and 450 000 pascals, preferably between 75 000 pascals and 300 000 pascals, and even more preferably between 100 000 pascals and 200 pascals. 000 Pascals. The extent of the measurement scale was determined by the inventors in relation to the vapor 4P0 representative of the pressure drop generated by the filtering system when the at least one filter cartridge is new. The range range of this scale is preferably determined so that it can follow the variation of the measurement 4P at least over a range between a zero lower bound (0 * 4P0) and an upper bound between 1.5 * 4P0 and 3 * 4P0, and preferably between 1.5 * 4PO and 2 * 4P0. For example, the scale extends between 0 Pascal and 150 000 Pascals. The method also comprises the definition of a high threshold Sh, predetermined, representative of a certain fouling and / or a low threshold Sb, representative a preferential passage (a leak).
    [0016] The method also comprises a test step during which said measurement Si is compared with the high threshold Sh, predetermined, and with the low threshold Sb predetermined so as to consider said at least one non-compliant filter cartridge when the measured pressure difference at the measurement step If fate of a range between said high threshold Sh and said low threshold Sb.
    [0017] In the case of a filter system comprising several filter cartridges, all the cartridges are considered non-compliant. Thus and when the pressure difference measurement reaches or exceeds the high threshold Sh, said at least one filter cartridge is considered non-compliant. It is then advisable to replace it with a new cartridge. It is important to note that this high threshold is however determined at a value of 4P representative of a filter cartridge integrates in particular a sterilizing cartridge integrates (reps or representative of a set of integrated filter cartridges in the case of a system multi-cartridge filter). According to an advantageous embodiment, which is developed subsequently, this high threshold Sh is determined, furthermore, sufficiently low, in order to avoid over-consumption of the compressors generating the flow of gas to be filtered. When the measurement of pressure difference reaches or falls below the low threshold Sb, said at least one filter cartridge has a risk of preferential passage (a leak). Said cartridge is considered as non-integral and therefore non-compliant. In the case of a filtering system with several filter cartridges, it is the set of filter cartridges that is considered unhealthy. In this set, all or some of the filter cartridges may be ungrateful. The method can then be followed by a step of identifying the non-integral filter cartridge (s) in this set, after their removal from the filtering system.
    [0018] According to one embodiment, the method may comprise a preliminary step of measuring the pressure difference APO representative of the pressure drop generated by the filtering system when the at least one filter cartridge is new. Advantageously, the method comprises a calibration step during which said high threshold Sh and / or the low threshold Sb are determined, in particular by calculation, as a function of the measured pressure difference APO. Thus, the high threshold Sh and the low threshold can be defined by the following formulas: Sh = f (APO) and Sb = g (APO) with f and g functions. For example, and according to one embodiment, the high threshold Sh and the low threshold Sb can be simply determined by the following relations: Sh = Kh * APO with Kh a constant.
    [0019] In the same way the low threshold is defined by the following formula: Sb = Kb * APO with Kb a constant. According to another embodiment, charts (or correspondence tables) can make it possible to know the values of the high and low thresholds as a function of the value of measured APO. Thus and according to this advantageous characteristic of the invention, the definition of the high threshold Sh and the low threshold Sb does not require knowing the specific characteristics of the filter cartridge to be tested. Also the implementation of the control method and the definition of the high and low thresholds can be done without knowing the specific technical characteristics of the filter cartridge. The implementation of the method and in particular the decision-making on the conformity of said at least one filter cartridge can be carried out without the use of computer means.
    [0020] Alternatively, and according to one embodiment, the method may comprise the following steps, implemented by computer means: a step of transmitting a signal comprising a measurement relating to the pressure difference 4P measured during the step; If - a step of recording in a computer file, at a time interval or continuously, of said measured pressure difference value. Measurements being performed at time t, said method may comprise a step of generating a computer file comprising, for each value of measured pressure difference, a temporal parameter t representative of the measurements. It is thus possible to follow the evolution of the pressure difference 4P, as a function of time. The method can thus provide for the generation of a curve representative of the evolution of the pressure difference 4P with respect to the time t and its display on a control screen. Typically at t = 0, the pressure difference measured corresponds to the pressure difference 4P0 when the cartridge or cartridges of the filter system are new. The implementation of computer means still allows the realization of a step of generating a warning signal Ae; Af when said measured pressure difference exits said range between said high threshold Sh and said low threshold Sb.
    [0021] Thus and in particular according to the diagram of FIG. 5, the method, when implemented by computer means, can comprise, after recording said high threshold Sh and / or said low threshold Sb, the following steps: the test step which comprises the comparison of the pressure difference measured during the measurement step Si with said low threshold (step S2 of the diagram) and the high threshold (step S3 of the diagram), - the generation of a warning signal Ae ; Af when said measured pressure difference reaches the high threshold Sh or the low threshold Sb.
    [0022] The implementation of computer means may allow, again, to perform the calibration step S01, automatically, and thus automatically generate the high threshold Sh and / or the low threshold Sb, after each renewal of the filter cartridges. Thus, the computer means allow the following steps to be performed: measuring MIES 1 and recording the pressure difference φ0 (step SOO of the diagram); setting the high threshold Sh and / or the low threshold Sb in relation to the pressure difference; 4P0 measured (step S01 of the diagram).
    [0023] For the determination step, the high threshold and the low threshold according to APO, it is possible to use the relationships described above. Thus, the entire process may be that illustrated in the diagram of FIG. 5, and which comprises the following steps: measuring step 501 (MES 1) for which the pressure difference 4P0 is measured when the cartridge or cartridges of the filter system are new, - the calibration step S02 (CALC ET) for which is defined, in particular by calculation, the high threshold Sh and the low threshold Sb in relation to the pressure difference APO, - the measuring step 51 (MES-2) in which is measured a pressure difference 4P representative of the pressure drop generated by the filter system Fi; F2, - the test step S2 during which said pressure difference measured in step 51 is compared with the low threshold Sb determined during the step S02, the test step S3 in which one compares said pressure difference measured in step Si with the low threshold Sh determined during step S02. According to this diagram, and in a general way: in the case where the pressure difference measured during the step Si is equal to or lower than the low threshold Sb, a "leak" warning signal is emitted, when the pressure difference measured in the step Si is equal to or greater than the high threshold Sh, a warning signal "fouling" is emitted.
    [0024] Steps S1, S2, S3 are renewed periodically at regular time intervals to ensure monitoring of the filter system over time. According to one embodiment, the value of the high threshold Sh can be between 1.3 * APO and 3 * APO, preferably between 1.4 * APO and 2 * APO, and even more preferentially between 1.4 * APO and 1.6 * APO. In this case, the constant Kh may thus be between 1.3 and 3, preferably between 1.4 and 2 and more preferably between 1.4 and 1.6. According to the findings of the inventors, in most cases, at a pressure difference measured at 3 * AP0, said at least one filter cartridge, in particular a sterilizing cartridge, can still be considered as integral in that the filtered gas can be considered sterile. However, and although the integrity of said at least one cartridge is not questioned, the pressure loss generated results in a significant overconsumption of the compressors necessary for carrying out the filtration. This is the reason why a high threshold of lower value is preferable, in particular between 1.4 * APO and 2 * APO, preferably between 1.4 * APO and 1.6 * APO. The definition of such a high threshold makes it possible to avoid these overconsumptions of the compressors.
    [0025] Regarding the value of the low threshold Sb, the latter may be between 0.7 * APO and 0.95 * APO, preferably between 0.88 * APO and 0.92 * APO. . The constant Kb can thus be between 0.7 and 0.95, preferably between 0.88 and 0.92.
    [0026] Figures 2 to 3 illustrate, by way of non-limiting examples, different representative curves of different scenarios for the filter cartridges controlled online. The example of Figure 2 illustrates a first scenario of the evolution of the measured pressure difference 4P, since t = 0 corresponding to the renewal of the filter cartridges of the filter system. According to this example, because of the fouling of the filter cartridges, the pressure difference 4P measured in the step Si increases gradually until it reaches and then exceeds the high threshold Sh defined as 1.5 * APO. When this high threshold Sh is reached, a warning signal Ae is emitted. This signal is interpreted as too much fouling. It is advisable to renew the said at least one filter cartridge.
    [0027] The example of Figure 3 illustrates a second scenario of the evolution of the measured pressure difference 4P, since t = 0 corresponding to the renewal of the filter cartridges of the filter system. According to this example, due to the fouling of the filter cartridges, the pressure difference 4P measured in step 51 gradually increases and then begins to decrease until reaching and falling below a low threshold defined as 0.9 * APO. When this low threshold Sb is reached, a warning signal Af is emitted. This warning signal is interpreted as a preferential passage in the filtering system (a leak), namely a lack of integrity. The example of Figure 4 illustrates a third scenario of the evolution of the measured pressure difference 4P, since t = 0 corresponding to the renewal of the filter cartridges of the filter system. According to this example, due to the fouling of the filter cartridges, the pressure difference 4P measured in step 51 gradually increases and then falls sharply while remaining between the upper and lower limits defined by the high threshold and the low threshold. The analysis of the curve, visually or by means of computer calculations can detect an anomaly. Thus the observation of jolts and / or abrupt variations can be interpreted as an anomaly on the gas circuit, especially at the level of the filter system. Tests: The present Applicant has carried out preliminary tests to verify the relevance of the control of the sterilizing filter cartridge integrity, by monitoring the measurement 4P, representative of the pressure drop of the filtering system. These tests were conducted on filter cartridges 6 cm in diameter. These are sterilizing cartridges performing a 0.01 micron filtration. These filter cartridges are used in a filter system illustrated in the photo of Figure 6 and whose housing receives 20 filter cartridges.
    [0028] This filter system is used to sterilize air that is then used in batch fermentation processes, in the type of installation shown in Figure 1. These cartridges include PALL CPFR brand cartridges and brand cartridges. PARKER ZCHT.
    [0029] A test bench, shown in photo in Figure 7 has also been designed. This test bench is connected to the factory compressed air source. This test bench comprises: - a flow meter 2, - a casing 3 intended to receive a filter cartridge to be tested, - a device 1 for measuring pressure difference, in this case a MAGNEHELIC differential pressure gauge whose scale of measurement the display extends from 0 to 15 kilo Pascals, - a flow control valve 4, - an isolation valve 5. This test bench allows the implementation of the test protocol which comprises the following steps: 1) Make sure that the zero point of the differential pressure gauge is correctly adjusted, 2) Place a new cartridge in the housing 3, 3) Close the valves 4 and 5, 4) Open the air supply valve of the factory network, 5) Open the isolation valve 5, 6) Open and adjust the flow control valve 4 to read the test flow determined by the flowmeter, 7) Check that the device correctly indicates the standard value (APO) determined for this cartridge , 8) Close the isolation valve 5, 9) Replace the cartridge new by a test cartridge (of the same type), 10) Open the isolation valve 5, 11) Read the differential pressure (4P). This test bench was used to control, in particular, the PALL CPFR filter cartridges, mentioned above, after one and a half years (1.5 years) of use for the filtration of air used in industrial fermentation processes. For the implementation of this test, the values of flow rate, pressure difference 4P0, high threshold Sh and low threshold Sb are as follows: Cartridge Test flow rate Pressure (1KPa = 10mb) at +/- 5 Nm3 / h Type Length 4130 Low threshold High threshold (standard) CPFR 20P 180 Nm3 / h 95 mb 70 mb 150 mb According to this test and similarly to the invention, consider: a) If 4P measured in step 11 of protocol is less than or equal to the low threshold Sb, the filter cartridge is not integral, b) If 4P measured in step 11 of the protocol is strictly greater than the low threshold and strictly lower than the high threshold, the cartridge is considered as integral and compliant , c) If 4P measured is greater than or equal to the high threshold, the cartridge is fouled and it is recommended to change it; such a cartridge is not necessarily to be considered as unhealthy. The used filter cartridges mentioned above were tested according to this protocol. Cartridges whose 4P is between the low threshold and the high threshold, considered as compliant, have been retained. Five cartridges considered as compliant were returned to the manufacturer for a standard integrity test, namely a manufacturer-recognized aerosol test, performed on a "Valairdata II type WVA203FFV" device from PARKER HANNIFIN, and by the manufacturer. PALL company, on a device "Integrity test Flowstar IV". All cartridges considered to comply with the test protocol were considered by the manufacturer to be safe.
    [0030] NOMENCLATURE 1. Device for measuring a difference in pressure, 2. Flowmeter (test bench), 3. Housing (test bench), 4. Flow control valve (test bench), 5. Isolation valve ( test bench), Ae. Dirt signal, Af. Leak signal, Cl. First pressure connection, C2. Second connection pressure, Fi; F2. Filter System, R. Fermentation Reactor, Sh High Threshold, Sb. Low threshold, 4P. Pressure difference (Step Si), APO. Pressure difference (for filter system with new cartridge (s)),
    权利要求:
    Claims (14)
    [0001]
    REVENDICATIONS1. A method for online monitoring of the integrity of a filtering system (F1; F2) implemented during an industrial process comprising filtering a gas through said filtering system, said filtering system (Fi; F2) comprising at least one filter cartridge, the method comprising at least the following steps: a measuring step (Si) in which a pressure difference 4P is measured representative of the pressure drop generated by the filtering system (F1; a test step (S2, S3) in which said measurement (Si) is compared with a predetermined high threshold (Sh) and a predetermined low threshold (Sb) so as to consider said at least one non-compliant filter cartridge when the pressure difference measured at the measuring step (Si) falls outside a range between said high threshold (Sh) and said low threshold (Sb).
    [0002]
    2. Method according to claim 1 comprising a preliminary step of measuring (501) the pressure difference 4P0 representative of the pressure drop generated by the filtering system when the at least one filtering cartridge is new, and a calibration step. during which the high threshold (Sh) and / or the low threshold (Sb) are determined, in particular by calculation, as a function of the measured difference in pressure 4P0.
    [0003]
    3. Method according to claim 1 or 2, 4P0 being the pressure drop generated by the filtering system when said at least one cartridge is new, and wherein the value of the high threshold (Sh) is between 1.3 * APO and 3 * APO.
    [0004]
    4. The method of claim 3, wherein the value of the high threshold (Sh) is between 1.4 * APO and 2 * APO and preferably between 1.4 * APO and 1.64P0. 30
    [0005]
    5. Method according to one of claims 1 to 4, 4P0 being the pressure drop generated by the filter system when said at least one cartridge is new andin which the value of the low threshold (Sb) is between 0.7 * 4P0 and 0.95 * 4P0, preferably between 0.88 * 4P0 and 0.92 * 4P0.
    [0006]
    6. Method according to one of claims 1 to 5, wherein the measurement of the pressure difference made during the measuring step (Si) is performed by means of a device for measuring a pressure difference having a sensitivity less than 750 Pascals, preferably less than or equal to 300 Pascals, and even more preferably between 50 Pascals and 200 Pascals, said device having a first pressure connection (C1), downstream of the filter system and a second connection of pressure (C2), upstream of the filter system.
    [0007]
    7. Method according to one of claims 1 to 6, comprising the following steps, implemented by computer means: - a step of transmitting a signal comprising a measurement relative to the pressure difference 4P measured at the time of l measurement step (Si); a step of recording in a computer file, at intervals or continuously, said measured pressure difference value.
    [0008]
    The method of claim 7 including a step of generating a warning signal (Ae; Af) when said measured pressure difference is outside said range between said high threshold (Sh) and said low threshold (Sb).
    [0009]
    9. Method according to one of claims 1 to 8, wherein the filter system (F1; F2) comprises a plurality of filter cartridges, said pressure difference measured at the measuring step (Si) being representative of the loss of charge generated by all the filter cartridges.
    [0010]
    10. Method according to one of claims 1 to 9 wherein the measurement sensitivity is less than 750 Pascals, preferably less than or equal to 300 Pascals, and even more preferably between 50 Pascals and 200 Pascals.
    [0011]
    11. Method according to one of claims 1 to 10, wherein the measurement scale comprises a range of between 75000 Pascals and 450 000 Pascals, preferably between 75 000 Pascals and 300 000 Pascals, and even more preferentially between 75,000 Pascals and 200,000 Pascals.
    [0012]
    12. Use of a method according to one of claims 1 to 11, wherein the industrial process is an industrial process having normal gas flow rates to said filter system greater than 100 Nm3 / H.
    [0013]
    13. Use of a method according to one of claims 1 to 11, wherein the industrial process is an industrial process for which said filtration is a sterilizing filtration.
    [0014]
    14. Use of the method according to claim 13 wherein the industrial process is an industrial fermentation process and in which the filter system (F1; F2) is used to treat air supplying the fermentation reactor (R) or the tank a material (G1) such as glucose feeding the fermentation reactor (R).
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    同族专利:
    公开号 | 公开日
    KR102339555B1|2021-12-16|
    EP3142770B1|2020-09-30|
    FR3021112B1|2016-06-24|
    US20170043290A1|2017-02-16|
    ES2837842T3|2021-07-01|
    CN106457116B|2020-03-06|
    WO2015173515A3|2016-04-28|
    MX2016014940A|2017-04-11|
    JP6681341B2|2020-04-15|
    KR20170002436A|2017-01-06|
    EP3142770A2|2017-03-22|
    JP2017519194A|2017-07-13|
    CN106457116A|2017-02-22|
    WO2015173515A2|2015-11-19|
    US10478765B2|2019-11-19|
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    法律状态:
    2015-06-01| PLFP| Fee payment|Year of fee payment: 2 |
    2015-11-20| PLSC| Publication of the preliminary search report|Effective date: 20151120 |
    2016-05-27| PLFP| Fee payment|Year of fee payment: 3 |
    2017-05-30| PLFP| Fee payment|Year of fee payment: 4 |
    2018-05-28| PLFP| Fee payment|Year of fee payment: 5 |
    2019-05-31| PLFP| Fee payment|Year of fee payment: 6 |
    2020-05-30| PLFP| Fee payment|Year of fee payment: 7 |
    2021-05-31| PLFP| Fee payment|Year of fee payment: 8 |
    优先权:
    申请号 | 申请日 | 专利标题
    FR1454355A|FR3021112B1|2014-05-15|2014-05-15|METHOD FOR INTEGRATING THE INTEGRITY OF A FILTER SYSTEM|FR1454355A| FR3021112B1|2014-05-15|2014-05-15|METHOD FOR INTEGRATING THE INTEGRITY OF A FILTER SYSTEM|
    US15/305,376| US10478765B2|2014-05-15|2015-05-13|Method for in-line control of the integrity of a filtering system|
    CN201580025229.3A| CN106457116B|2014-05-15|2015-05-13|Method for controlling the integrity of a filtration system on-line|
    PCT/FR2015/051257| WO2015173515A2|2014-05-15|2015-05-13|Method for in-line control of the integrity of a filtering system|
    JP2016565067A| JP6681341B2|2014-05-15|2015-05-13|Inline control method of integrity of filtering system|
    EP15728056.1A| EP3142770B1|2014-05-15|2015-05-13|Method for in-line control of the integrity of a filtering system|
    ES15728056T| ES2837842T3|2014-05-15|2015-05-13|Method for online monitoring of the integrity of a filter system|
    MX2016014940A| MX2016014940A|2014-05-15|2015-05-13|Method for in-line control of the integrity of a filtering system.|
    KR1020167031412A| KR102339555B1|2014-05-15|2015-05-13|Method for in-line control of the integrity of a filtering system|
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